Amber Leaver
Amber Leaver
• Asst Professional Researcher - Neurology


My work balances translational and basic-science research to achieve a mechanistic understanding of brain-network function. Specifically, I use magnetic resonance imaging (MRI) to target:

• dysfunction in interoceptive disorders like depression, tinnitus, and chronic pain, where internal thoughts and sensations are disrupted,
• improved approaches to therapeutic neurostimulation, and
• basic information processing in auditory and fronto-striatal networks.

Click here to visit my Google Scholar profile.

Click here to access stimuli used in Leaver & Rauschecker 2016 J Neurosci.


Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression.
Njau S; Joshi SH; Espinoza R; Leaver AM; Vasavada M; Marquina A; Woods RP; Narr KL;

PMID: 27327561    DOI: 10.1503/jpn.150177   
Variations in myo-inositol in fronto-limbic regions and clinical response to electroconvulsive therapy in major depression.
Njau S; Joshi SH; Leaver AM; Vasavada M; Van Fleet J; Espinoza R; Narr KL;

PMID: 27285661    DOI: 10.1016/j.jpsychires.2016.05.012   
Intrinsic network activity in tinnitus investigated using functional MRI.
Leaver AM; Turesky TK; Seydell-Greenwald A; Morgan S; Kim HJ; Rauschecker JP;

PMID: 27091485    DOI: 10.1002/hbm.23204   
Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder.
Wade BS; Joshi SH; Njau S; Leaver AM; Vasavada M; Woods RP; Gutman BA; Thompson PM; Espinoza R; Narr KL;

PMID: 27067127    DOI: 10.1038/npp.2016.48   
Auditory-limbic interactions in chronic tinnitus: Challenges for neuroimaging research.
Leaver AM; Seydell-Greenwald A; Rauschecker JP;

PMID: 26299843    DOI: 10.1016/j.heares.2015.08.005   
Structural Plasticity of the Hippocampus and Amygdala Induced by Electroconvulsive Therapy in Major Depression.
Joshi SH; Espinoza RT; Pirnia T; Shi J; Wang Y; Ayers B; Leaver A; Woods RP; Narr KL;

PMID: 25842202    DOI: 10.1016/j.biopsych.2015.02.029    PMCID: NIHMS669720 [Available on 02/15/17]
Functional Topography of Human Auditory Cortex.
Leaver AM; Rauschecker JP;

PMID: 26818527    DOI: 10.1523/JNEUROSCI.0226-15.2016    PMCID: PMC4728734 [Available on 07/27/16]
Structural connectivity and response to ketamine therapy in major depression: A preliminary study.
Vasavada MM; Leaver AM; Espinoza RT; Joshi SH; Njau SN; Woods RP; Narr KL;

PMID: 26630613    DOI: 10.1016/j.jad.2015.11.018    PMCID: NIHMS739334 [Available on 01/15/17]
Altered resting-state functional connectivity in late-life depression: A cross-sectional study.
Eyre HA; Yang H; Leaver AM; Van Dyk K; Siddarth P; Cyr NS; Narr K; Ercoli L; Baune BT; Lavretsky H;

PMID: 26433760    DOI: 10.1016/j.jad.2015.09.011    PMCID: NIHMS726383 [Available on 01/01/17]
Modulation of intrinsic brain activity by electroconvulsive therapy in major depression.
Leaver AM; Espinoza R; Pirnia T; Joshi SH; Woods RP; Narr KL;

PMID: 26878070    DOI: 10.1016/j.bpsc.2015.09.001   
Electroconvulsive therapy and structural neuroplasticity in neocortical, limbic and paralimbic cortex.
Pirnia T; Joshi SH; Leaver AM; Vasavada M; Njau S; Woods RP; Espinoza R; Narr KL;

PMID: 27271858    DOI: 10.1038/tp.2016.102    PMCID: PMC4931600
Desynchronization and Plasticity of Striato-frontal Connectivity in Major Depressive Disorder.
Leaver AM; Espinoza R; Joshi SH; Vasavada M; Njau S; Woods RP; Narr KL;

PMID: 26400916    DOI: 10.1093/cercor/bhv207   
Connectome and schizophrenia.
Narr KL; Leaver AM;

PMID: 25768086    DOI: 10.1097/YCO.0000000000000157   
Random Forest Classification of Depression Status Based On Subcortical Brain Morphometry Following Electroconvulsive Therapy.
Wade BS; Joshi SH; Pirnia T; Leaver AM; Woods RP; Thompson PM; Espinoza R; Narr KL;

PMID: 26413200    DOI: 10.1109/ISBI.2015.7163824   
Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression.
Lyden H; Espinoza RT; Pirnia T; Clark K; Joshi SH; Leaver AM; Woods RP; Narr KL;

PMID: 24713861    DOI: 10.1038/tp.2014.21    PMCID: PMC4012285
Distinct cortical locations for integration of audiovisual speech and the McGurk effect.
Erickson LC; Zielinski BA; Zielinski JE; Liu G; Turkeltaub PE; Leaver AM; Rauschecker JP;

PMID: 24917840    DOI: 10.3389/fpsyg.2014.00534    PMCID: PMC4040936
Diffusion imaging of auditory and auditory-limbic connectivity in tinnitus: preliminary evidence and methodological challenges.
Seydell-Greenwald A; Raven EP; Leaver AM; Turesky TK; Rauschecker JP;

PMID: 25050181    DOI: 10.1155/2014/145943    PMCID: PMC4090469
Functional MRI evidence for a role of ventral prefrontal cortex in tinnitus.
Seydell-Greenwald A; Leaver AM; Turesky TK; Morgan S; Kim HJ; Rauschecker JP;

PMID: 22982009    DOI: 10.1016/j.brainres.2012.08.052    PMCID: NIHMS405641
Cortico-limbic morphology separates tinnitus from tinnitus distress.
Leaver AM; Seydell-Greenwald A; Turesky TK; Morgan S; Kim HJ; Rauschecker JP;

PMID: 22493571    DOI: 10.3389/fnsys.2012.00021    PMCID: PMC3319920
Dysregulation of limbic and auditory networks in tinnitus.
Leaver AM; Renier L; Chevillet MA; Morgan S; Kim HJ; Rauschecker JP;

PMID: 21220097    DOI: 10.1016/j.neuron.2010.12.002    PMCID: NIHMS270452
Edges can eliminate the appearance of the contrast asynchrony.
Shapiro AG; Leaver AM;

PMID: 20883337    DOI: 10.1111/j.1475-1313.2010.00737.x   
Tuning out the noise: limbic-auditory interactions in tinnitus.
Rauschecker JP; Leaver AM; Mühlau M;

PMID: 20620868    DOI: 10.1016/j.neuron.2010.04.032    PMCID: NIHMS201242
Cortical representation of natural complex sounds: effects of acoustic features and auditory object category.
Leaver AM; Rauschecker JP;

PMID: 20519535    DOI: 10.1523/JNEUROSCI.0296-10.2010    PMCID: NIHMS203724
Segregation of vowels and consonants in human auditory cortex: evidence for distributed hierarchical organization.
Obleser J; Leaver AM; Vanmeter J; Rauschecker JP;

PMID: 21738513    DOI: 10.3389/fpsyg.2010.00232    PMCID: PMC3125530
Brain activation during anticipation of sound sequences.
Leaver AM; Van Lare J; Zielinski B; Halpern AR; Rauschecker JP;

PMID: 19244522    DOI: 10.1523/JNEUROSCI.4921-08.2009    PMCID: NIHMS97319
Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study.
Eyre HA, Acevedo B, Yang H, Siddarth P, Van Dyk K, et al.
. 2000-Dec;
PMID: 27060939