David Shattuck
David W. Shattuck, Ph.D.
• Professor - Department of Neurology
635 Charles E. Young Dr. South
Suite 225
Los Angeles, CA 90095


My research interests are focused on the development and application of novel computational approaches for the processing and analysis of brain images. This work has developed novel algorithms related to brain image analysis, including image segmentation topological filtering of data, image registration, and interactive delineation of data. Many of these methods are available in our publicly released software package, BrainSuite (

Area(s) of Expertise

image analysis, software engineering


Mapping the human connectome.
Toga AW; Clark KA; Thompson PM; Shattuck DW; Van Horn JD;
Neurosurgery. 2012-Jul;71(1-5):1
PMID: 22705717    DOI: 10.1227/NEU.0b013e318258e9ff    PMCID: NIHMS377780
An invariant shape representation using the anisotropic Helmholtz equation.
Joshi AA; Ashrafulla S; Shattuck DW; Damasio H; Leahy RM;
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2012-Dec;15(607-14):Pt 3
PMID: 23286181    DOI: 10.1136/amiajnl-2011-000525    PMCID: NIHMS456267
The Center for Computational Biology: resources, achievements, and challenges.
Toga AW; Dinov ID; Thompson PM; Woods RP; Van Horn JD; Shattuck DW; Parker DS;
Journal of the American Medical Informatics Association : JAMIA. 2011-Nov-10;19(202-6):2
PMID: 22081221    DOI: 10.1136/amiajnl-2011-000525    PMCID: PMC3277626
DigiWarp: a method for deformable mouse atlas warping to surface topographic data.
Joshi AA; Chaudhari AJ; Li C; Dutta J; Cherry SR; Shattuck DW; Toga AW; Leahy RM;
Physics in medicine and biology. 2010-Oct-21;55(6197-214):20
PMID: 20885019    DOI: 10.1088/0031-9155/55/20/011    PMCID: NIHMS276339
Sulcal set optimization for cortical surface registration.
Joshi AA; Pantazis D; Li Q; Damasio H; Shattuck DW; Toga AW; Leahy RM;
NeuroImage. 2010-Apr-15;50(950-9):3
PMID: 20056160    DOI: 10.1016/j.neuroimage.2009.12.064    PMCID: NIHMS168767
Visualization of image data from cells to organisms.
Walter T; Shattuck DW; Baldock R; Bastin ME; Carpenter AE; Duce S; Ellenberg J; Fraser A; Hamilton N; Pieper S; Ragan MA; Schneider JE; Tomancak P; Hériché JK;
Nature methods. 2010-Mar;7(S26-41):3 Suppl
PMID: 20195255    DOI: 10.1038/nmeth.1431    PMCID: NIHMS456024
Visualizing biological data-now and in the future.
O'Donoghue SI; Gavin AC; Gehlenborg N; Goodsell DS; Hériché JK; Nielsen CB; North C; Olson AJ; Procter JB; Shattuck DW; Walter T; Wong B;
Nature methods. 2010-Mar;7(S2-4):3 Suppl
PMID: 20195254    DOI: 10.1038/nmeth.f.301   
Comparison of landmark-based and automatic methods for cortical surface registration.
Pantazis D; Joshi A; Jiang J; Shattuck DW; Bernstein LE; Damasio H; Leahy RM;
NeuroImage. 2010-Feb-1;49(2479-93):3
PMID: 19796696    DOI: 10.1016/j.neuroimage.2009.09.027    PMCID: NIHMS150383
Joshi AA; Chaudhari AJ; Li C; Shattuck DW; Dutta J; Leahy RM; Toga AW;
Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging. 2009-Aug-7;2009(366-369)
PMID: 21072317    DOI: 10.1109/ISBI.2009.5193060   
Active fibers: matching deformable tract templates to diffusion tensor images.
Eckstein I; Shattuck DW; Stein JL; McMahon KL; de Zubicaray G; Wright MJ; Thompson PM; Toga AW;
NeuroImage. 2009-Aug;47 Suppl 2(T82-9)
PMID: 19457360    DOI: 10.1016/j.neuroimage.2009.01.065    PMCID: NIHMS96332
Optimization of Landmark Selection for Cortical Surface Registration.
Joshi A; Pantazis D; Damasio H; Shattuck D; Li Q; Leahy R;
Proceedings / CVPR, IEEE Computer Society Conference on Computer Vision and Pattern Recognition. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. 2009-Jun-1;20-25(699-706)
PMID: 20717476    DOI: 10.1109/CVPR.2009.5206560   
A parameterization-based numerical method for isotropic and anisotropic diffusion smoothing on non-flat surfaces.
Joshi AA; Shattuck DW; Thompson PM; Leahy RM;
IEEE transactions on image processing : a publication of the IEEE Signal Processing Society. 2009-Jun;18(1358-65):6
PMID: 19423447    DOI: 10.1109/TIP.2009.2016163    PMCID: NIHMS133670
Semi-automated method for delineation of landmarks on models of the cerebral cortex.
Shattuck DW; Joshi AA; Pantazis D; Kan E; Dutton RA; Sowell ER; Thompson PM; Toga AW; Leahy RM;
Journal of neuroscience methods. 2009-Apr-15;178(385-92):2
PMID: 19162074    DOI: 10.1016/j.jneumeth.2008.12.025    PMCID: NIHMS133687
Online resource for validation of brain segmentation methods.
Shattuck DW; Prasad G; Mirza M; Narr KL; Toga AW;
NeuroImage. 2009-Apr-1;45(431-9):2
PMID: 19073267    DOI: 10.1016/j.neuroimage.2008.10.066    PMCID: NIHMS100392
A diffusion tensor imaging tractography algorithm based on Navier-Stokes fluid mechanics.
Hageman NS; Toga AW; Narr KL; Shattuck DW;
IEEE transactions on medical imaging. 2009-Mar;28(348-60):3
PMID: 19244007    DOI: 10.1109/TMI.2008.2004403    PMCID: NIHMS108592
Genetics of brain fiber architecture and intellectual performance.
Chiang MC; Barysheva M; Shattuck DW; Lee AD; Madsen SK; Avedissian C; Klunder AD; Toga AW; McMahon KL; de Zubicaray GI; Wright MJ; Srivastava A; Balov N; Thompson PM;
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009-Feb-18;29(2212-24):7
PMID: 19228974    DOI: 10.1523/JNEUROSCI.4184-08.2009    PMCID: NIHMS96956
Mean diffusivity: a biomarker for CSF-related disease and genetic liability effects in schizophrenia.
Narr KL; Hageman N; Woods RP; Hamilton LS; Clark K; Phillips O; Shattuck DW; Asarnow RF; Toga AW; Nuechterlein KH;
Psychiatry research. 2009-Jan-30;171(20-32):1
PMID: 19081707    DOI: 10.1016/j.pscychresns.2008.03.008    PMCID: NIHMS92131
A framework for brain registration via simultaneous surface and volume flow.
Joshi A; Leahy R; Toga AW; Shattuck D;
Information processing in medical imaging : proceedings of the ... conference. 2009-Dec;21(576-88)
PMID: 19694295    DOI: 10.1109/CVPR.2009.5206560   
Meeting the Challenges of Neuroimaging Genetics.
de Zubicaray GI; Chiang MC; McMahon KL; Shattuck DW; Toga AW; Martin NG; Wright MJ; Thompson PM;
Brain imaging and behavior. 2008-Dec-1;2(258-263):4
PMID: 20016769    DOI: 10.1007/s11682-008-9029-0   
Construction of a 3D probabilistic atlas of human cortical structures.
Shattuck DW; Mirza M; Adisetiyo V; Hojatkashani C; Salamon G; Narr KL; Poldrack RA; Bilder RM; Toga AW;
NeuroImage. 2008-Feb-1;39(1064-80):3
PMID: 18037310    DOI: 10.1016/j.neuroimage.2007.09.031    PMCID: NIHMS39232
Visualization tools for high angular resolution diffusion imaging.
Shattuck DW; Chiang MC; Barysheva M; McMahon KL; de Zubicaray GI; Meredith M; Wright MJ; Toga AW; Thompson PM;
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2008-Dec;11(298-305):Pt 2
PMID: 18982618    DOI: 10.1016/j.neuroimage.2007.09.031    PMCID: NIHMS284221
Surface-constrained volumetric brain registration using harmonic mappings.
Joshi AA; Shattuck DW; Thompson PM; Leahy RM;
IEEE transactions on medical imaging. 2007-Dec;26(1657-69):12
PMID: 18092736    DOI: 10.1016/j.neuroimage.2007.09.031   
Registration of cortical surfaces using sulcal landmarks for group analysis of MEG data.
Joshi AA; Shattuck DW; Thompson PM; Leahy RM;
International congress series / Excerpta Medica. 2007-Jun-1;1300(229-232)
PMID: 20824115    DOI: 10.1016/j.ics.2006.12.052   
Testosterone treatment in multiple sclerosis: a pilot study.
Sicotte NL; Giesser BS; Tandon V; Klutch R; Steiner B; Drain AE; Shattuck DW; Hull L; Wang HJ; Elashoff RM; Swerdloff RS; Voskuhl RR;
Archives of neurology. 2007-May;64(683-8):5
PMID: 17502467    DOI: 10.1001/archneur.64.5.683   
Genetic algorithms for finite mixture model based voxel classification in neuroimaging.
Tohka J; Krestyannikov E; Dinov ID; Graham AM; Shattuck DW; Ruotsalainen U; Toga AW;
IEEE transactions on medical imaging. 2007-May;26(696-711):5
PMID: 17518064    DOI: 10.1109/TMI.2007.895453    PMCID: NIHMS327487
Brain image registration using cortically constrained harmonic mappings.
Joshi A; Shattuck D; Thompson P; Leahy R;
Information processing in medical imaging : proceedings of the ... conference. 2007-Dec;20(359-71)
PMID: 17633713    DOI: 10.1128/MCB.00757-06   
Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis.
MacKenzie-Graham A; Tinsley MR; Shah KP; Aguilar C; Strickland LV; Boline J; Martin M; Morales L; Shattuck DW; Jacobs RE; Voskuhl RR; Toga AW;
NeuroImage. 2006-Sep;32(1016-23):3
PMID: 16806982    DOI: 10.1016/j.neuroimage.2006.05.006   
Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations.
Sicotte NL; Salamon G; Shattuck DW; Hageman N; Rüb U; Salamon N; Drain AE; Demer JL; Engle EC; Alger JR; Baloh RW; Deller T; Jen JC;
Neurology. 2006-Aug-8;67(519-21):3
PMID: 16894121    DOI: 10.1212/01.wnl.0000227960.38262.0c   
LONI visualization environment.
Dinov ID; Valentino D; Shin BC; Konstantinidis F; Hu G; MacKenzie-Graham A; Lee EF; Shattuck D; Ma J; Schwartz C; Toga AW;
Journal of digital imaging. 2006-Jun;19(148-58):2
PMID: 16598642    DOI: 10.1007/s10278-006-0266-8    PMCID: PMC3045182
Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice location.
Fennema-Notestine C; Ozyurt IB; Clark CP; Morris S; Bischoff-Grethe A; Bondi MW; Jernigan TL; Fischl B; Segonne F; Shattuck DW; Leahy RM; Rex DE; Toga AW; Zou KH; Brown GG;
Human brain mapping. 2006-Feb;27(99-113):2
PMID: 15986433    DOI: 10.1002/hbm.20161    PMCID: NIHMS46876
Segmentation of skull and scalp in 3-D human MRI using mathematical morphology.
Dogdas B; Shattuck DW; Leahy RM;
Human brain mapping. 2005-Dec;26(273-85):4
PMID: 15966000    DOI: 10.1002/hbm.20159   
Analysis of the brain-stem white-matter tracts with diffusion tensor imaging.
Salamon N; Sicotte N; Alger J; Shattuck D; Perlman S; Sinha U; Schultze-Haakh H; Salamon G;
Neuroradiology. 2005-Dec;47(895-902):12
PMID: 16158279    DOI: 10.1007/s00234-005-1439-8   
The human cerebral cortex on MRI: value of the coronal plane.
Salamon N; Sicotte N; Mongkolwat P; Shattuck D; Salamon G;
Surgical and radiologic anatomy : SRA. 2005-Dec;27(431-43):5
PMID: 16307199    DOI: 10.1007/s00276-005-0022-7   
A framework for registration, statistical characterization and classification of cortically constrained functional imaging data.
Joshi AA; Shattuck DW; Thompson PM; Leahy RM;
Information processing in medical imaging : proceedings of the ... conference. 2005-Dec;19(186-96)
PMID: 17354695    DOI: 10.1002/hbm.20159   
A meta-algorithm for brain extraction in MRI.
Rex DE; Shattuck DW; Woods RP; Narr KL; Luders E; Rehm K; Stoltzner SE; Stolzner SE; Rottenberg DA; Toga AW;
NeuroImage. 2004-Oct;23(625-37):2
PMID: 15488412    DOI: 10.1016/j.neuroimage.2004.06.019   
Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.
Jen JC; Chan WM; Bosley TM; Wan J; Carr JR; Rüb U; Shattuck D; Salamon G; Kudo LC; Ou J; Lin DD; Salih MA; Kansu T; Al Dhalaan H; Al Zayed Z; MacDonald DB; Stigsby B; Plaitakis A; Dretakis EK; Gottlob I; Pieh C; Traboulsi EI; Wang Q; Wang L; Andrews C; Yamada K; Demer JL; Karim S; Alger JR; Geschwind DH; Deller T; Sicotte NL; Nelson SF; Baloh RW; Engle EC;
Science (New York, N.Y.). 2004-Jun-4;304(1509-13):5676
PMID: 15105459    DOI: 10.1126/science.1096437    PMCID: NIHMS12091
Joshi AA; Shattuck DW; Thompson PM; Leahy RM;
Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging. 2004-Apr-1;1(428-431)
PMID: 20721316    DOI: 10.1109/ISBI.2004.1398566   
A multimodal, multidimensional atlas of the C57BL/6J mouse brain.
MacKenzie-Graham A; Lee EF; Dinov ID; Bota M; Shattuck DW; Ruffins S; Yuan H; Konstantinidis F; Pitiot A; Ding Y; Hu G; Jacobs RE; Toga AW;
Journal of anatomy. 2004-Feb;204(93-102):2
PMID: 15032916    DOI: 10.1111/j.1469-7580.2004.00264.x    PMCID: PMC1571243
The informatics of a C57BL/6J mouse brain atlas.
MacKenzie-Graham A; Jones ES; Shattuck DW; Dinov ID; Bota M; Toga AW;
Neuroinformatics. 2003-Dec;1(397-410):4
PMID: 15043223    DOI: 10.1385/NI:1:4:397   
Internet2-based 3D PET image reconstruction using a PC cluster.
Shattuck DW; Rapela J; Asma E; Chatzioannou A; Qi J; Leahy RM;
Physics in medicine and biology. 2002-Aug-7;47(2785-95):15
PMID: 12200939    DOI: 10.1385/NI:1:4:397   
BrainSuite: an automated cortical surface identification tool.
Shattuck DW; Leahy RM;
Medical image analysis. 2002-Jun;6(129-42):2
PMID: 12045000    DOI: 10.1385/NI:1:4:397   
Automated graph-based analysis and correction of cortical volume topology.
Shattuck DW; Leahy RM;
IEEE transactions on medical imaging. 2001-Nov;20(1167-77):11
PMID: 11700742    DOI: 10.1109/42.963819   
Qualitative and quantitative evaluation of six algorithms for correcting intensity nonuniformity effects.
Arnold JB; Liow JS; Schaper KA; Stern JJ; Sled JG; Shattuck DW; Worth AJ; Cohen MS; Leahy RM; Mazziotta JC; Rottenberg DA;
NeuroImage. 2001-May;13(931-43):5
PMID: 11304088    DOI: 10.1006/nimg.2001.0756   
Magnetic resonance image tissue classification using a partial volume model.
Shattuck DW; Sandor-Leahy SR; Schaper KA; Rottenberg DA; Leahy RM;
NeuroImage. 2001-May;13(856-76):5
PMID: 11304082    DOI: 10.1006/nimg.2000.0730